Center for Human Cell Therapy Boston

The Connel O'Reilly Cell Manipulation Core Facility (CMCF) was established as a Dana Farber Cancer Institute Core Facility in 1996. In 2005, CMCF moved to a new GMP facility which encompasses approximately 6,500 square footage that is dedicated to the production of clinical grade cellular products. The CMCF routinely supports approximately 30 active clinical trials. This includes trails that require routine cellular processing (361 products/year in 2007) as well as trials that require more extensive processing of manufactured products under INDs and IDE (351/year in 2007). 

The manufacturing facility is classified as an ISO 7 cleanroom that is divided into two separate lab areas for clinical cell processing, One lab is dedicated to the production of products requiring minimal manipulation and the referred to as the Cell Processing (CP) area. The other processing lab, referred to as the Gene Therpay (GT) area, is where the transfection of cells with viral vectors or long term cell cultures are processed. The cryopreservation areas occupies 1200 square feet of space. This areas has the capacity to hold twenty large liquid nitrogen storage units that will store up to 1,200 patient products or 79,000 vials of research samples per unit. The CMCF is fully equipped to provide extensive cell processing capabilities and includes a Quality Assurance and Control lab.