Current Projects at the CHCT

Current Projects with IND Approval:

Title: “Virus Targeted Immunotherapy for Epstein-Barr Virus Associated Nasopharyngeal Carcinoma”

PI: Fred Wang, M.D.
Participating Institutions: Brigham and Women's Hospital, Dana-Farber Cancer Institute

Title: “Artificial Antigen Presenting Cells Generate CD8+ Antigen Specific T-cells for Adoptive Immunotherapy: Challenges of Clinical Translation”

PI: Marcus Butler, M.D.
Participating Institutions: Dana-Farber Cancer Institute, Brigham and Women's Hospital, Massachusetts General Hospital

Title: “Invariant Natural Killer T Cells (iNKT Cells) For Clinical Trials in Advanced Cancer”

PI: Steven Balk, M.D., Ph.D.
Participating Institutions: Beth Israel Deaconess Medical Center & Harvard Medical School

Title: “Prostanglandin E2 regulates vertebrate Hematopoietic Stem Cell Homeostasis”

PI: Len Zon, M.D.
Participating Institutions: Children's Hospital Boston

Current Projects at the CHCT's Translational Cell Therapy Lab

Title: “Diaphragmatic Repair With Autologous Tendon Engineered from Mesenchymal Amniocytes”

PI: Dario O. Fauza, M.D.
Participating Institutions: Children's Hospital Boston, Dana-Farber Cancer Institute

Title: “Genetically Engineered T-Cells for Glioblastoma Therapy”

PI: Bob Carter, M.D., Ph.D.
Participating Institutions: Massachusetts General Hospital

Title: “Mesenchymal stem cell-based therapy for human brain tumors”

PI: Rona Carrol, Ph.D.
Participating Institutions: Brigham and Women's Hospital

Title: “Autologous Bone Marrow-Derived Mesenchymal Stem Cells for Cartilage Repair”

PI: Myron Spector, Ph.D.
Participating Institutions: Brigham and Women's Hospital

Other Projects Supported

Title: “Feasibility of Using RNAi to Generate HIV-resistant Primary CD4 T Cells”

PI: Premlata Shankar, M.D.
Participating Institutions: CBR Institute for Biomedical Research